I agree that the bike was eventually screwed by the control tyre which mainly became apparent in retrospect as you say, and the whole integrated chassis concept became completely unviable anyway when they brought in the engine number limitations.Stoner is subject to stress, we know. Stress can be a cause of allergic symptoms as much as the allergene itself, and he was surely stressed in 2009. The Ducati was already basically a scrxxed project. Why?
One aspect that is often forgotten (but that was and is very present in the mind of people working at Borgo Panigale) is that the rule freezing the number of engines (and the engine themselves) was basically the final nail in the coffin of Preziosi's Ducati -- as it was the only bike using the engine as a stressed member.
After the single tire rule, the ability to change frame stiffness and weight distribution became mandatory to adjust to the new specs, and Ducati found themselves fuXXed.
They should have done what Dall'Igna did last year immediately, but went the wrong way (also the rules didn't help then). They wasted the Rossi years trying to work around the problem, when what was actually needed was a completely new chassis AND a smaller and lighter engine, to fit into the new frame in the proper way with a possibility to adjust its position properly.
This is a key to understand what really happened, and is consistently ignored by our forum gurus. There are others keys as well. Of course it's easy to tell now, it wasn't along the way.
Disagree about 2009. He had no dnfs that year (he had I DNS after the warm-up lap off in the last race attributed to a faulty tyre warmer) . He won Qatar handily, had competitive pace but not the physical endurance to finish races till his break, then more than competitive pace and no problems with physical endurance on his return.
You are in fact buying into the Ducati narrative which he has said both in his book and on other occasions was, along with I am sure the moderately widespread spitefulness towards him during his travails, the major cause of his disillusionment with both Ducati and the sport. He clearly believes his problem was mainly a physical one, and there is no evidence that it was otherwise.
I am a physician myself, and on first impression considered lactose intolerance a rather prosaic explanation, but it did eventually all hang together medically. If it was "stress", why did he have no physical endurance problems in 2010 when the bike was undeniably terrible and he was putting it down frequently?